Non-communicable diseases (NCDs) like hypertension and diabetes are now predominant disease burden globally including in low and middle-income settings. Eighty percent of deaths from these non-infectious diseases occur in the developing world. NCDs have now surpassed infectious diseases as the leading causes of death, causing 63 percent of global mortality. Nearly 80 percent of these deaths take place in low and middle-income countries. High blood pressure alone is the number one risk factor for death worldwide, causing up to 9.4 million deaths per year. While approximately 40 percent of people in developed countries are hypertensive, the prevalence in low and middle-income countries is already greater than 30 percent and, in some places, exceeds 50 percent. With urbanization and technologization taking hold around the world, the NCD burden may grow worse and signifies one of the major health challenges of the 21st century.